NET Framework 4.6 is a full framework for everything related to .NET, but lacks libraries & runtime optimized for multi-platform (Windows, Linux and Mac) and cloud deployments
NET Core on the other hand is a subset of .NET Framework 4.6 which is mainly optimized for multi-platform and cloud deployments
NET Native is mainly used to develop Universal Apps which will be quite optimized to run on any device and platform, natively (not for the web apps though)
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